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Referencias bibliográficas

Libro, “La dieta Budwig revisada”, autor Dr. Raymond Hílu,

Libro “Grasas saludables” Autor: Néstor Palmetti,

Revista Discovery Salud, http://www.dsalud.com/

Libro "La Gran Revolución de las Grasas" Sacha Barrio Healey

Libro ¿Podemos vivir 150 años? del autor Mikhail Tombak.

Worldwide Praise for PEO Solution: The New Clinical Tool for Physicians, Brian Scott Peskin, http://www.brianpeskin.com/

Libro “Por qué los animales no sufren infarto… y los hombres sí” autor Dr. Matthias Rath

Libro , “El milagro del lino” título original “Leinöl macht glücklich: Das blaue Ernährungswunder” autor Dr. Hans-Ulrich Grimm

E. C. Rizos, E. E. Ntzani, E. Bika, M. S. Kostapanos and M. S. Elisaf, “Association between Omega-3 Fatty Acid Supplementation and Risk of Major Cardiovascular Dis- ease Events: A Systematic Review and Meta-Analysis,” The Journal of the American Medical Association, Vol. 308, No. 10, 2012, pp.1024-1033. doi:10.1001/2012.jama.11374

S. M. Kwak, S. K. Myung, Y. J. Lee, H. G. Seo and for the Korean Meta-Analysis Study Group, “Efficacy of Omega-3 Fatty Acid Supplements (Eicosapentaenoic Acid and Docosahexaenoic Acid) in the Secondary Pre- vention of Cardiovascular Disease: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials,” Archives of Internal Medicine, Vol. 172, No. 9, 2012, pp.686-694. doi:10.1001/archinternmed.2012.262

G. Barceló-Coblijn, E. J. Murphy, R. Othman, M. H. Moghadasian, T. Kashour and J. K. Friel, “Flaxseed Oil and Fish-Oil Capsule Consumption Alters Human Red Blood Cell n-3 Fatty Acid Composition: A Multiple- Dosing Trial Comparing 2 Sources of n-3 Fatty Acid,” The American Journal of Clinical Nutrition, Vol. 88, No. 3, 2008, pp. 801-809. www.ncbi.nlm.nih.gov/pubmed/18779299

A. Welch, S. Shakya-Shrestha, M. Lentjes, N. J. Ware- ham and K. Khaw, “Dietary Intake and Status of N-3 Polyunsaturated Fatty Acids in a Population of Fish-Eat- ing and Non-Fish-Eating Meat-Eaters, Vegetarians, and Vegans and the Precursor-Product Ratio of a-Linolenic Acid to Long-Chain N-3 Polyunsaturated Fatty Acids: Results From the EPIC-Norfolk [Cancer & Nutrition Study] Cohort,” The American Journal of Clinical Nutri- tion, Vol. 92, No. 5, 2010, pp. 1040-1051. doi:10.3945/ajcn.2010.29457

M. Plourde and S. C. Cunnane, “Extremely Limited Syn- thesis of Long-Chain Polyunsaturates in Adults: Implica- tions for Their Dietary Essentiality and Use as Supple- ments,” Applied Physiology, Nutrition, and Metabolism, Vol. 32, No. 4, 2007, pp. 619-634. doi:10.1139/H07-034

R. Khoshdel, S. L. Carney, B. R. Nair and A. Gillies, “A Better Management of Cardiovascular Diseases by Pulse Wave Velocity: Combining Clinical Practice with Clini- cal Research Using Evidence-Based Medicine, Clinical Medicine & Research, Vol. 5, No. 1, 2007, pp. 45-52. doi:10.3121/cmr.2007.708

The Risk and Prevention Study Collaborative Group, “n-3 Fatty Acids in Patients with Multiple Cardiovascular Risk Factors,” New England Journal of Medicine, Vol. 368, No. 19, 2013, pp. 1800-1808.

E. Topol and Heartwire, “No Benefit of Fish Oil in High Risk Patients,” 2013. www.theheart.org/article/1536889.do

S. Young and S. Parthasarathy, “Why Are Low-Density Lipoproteins Atherogenic?” Western Journal of Medicine, Vol. 160, No. 2, 1994, pp. 1-18. www.ncbi.nlm.nih.gov/pubmed/8160466?dopt=Abstract

J. H. Chin, S. Azhar and B. B. Hoffman, “Inactivation of Endothelial Derived Relaxing Factor by Oxidized Lipo- proteins,” The Journal of Clinical Investigation, Vol. 89, No. 1, 1992, pp. 10-18. doi:10.1172/JCI115549

P. E. Wainwright, Y. S. Huang, B. Bulman-Fleming, et al., “The Effects of Dietary n-3/n-6 Ratio on Brain De- velopment in the Mouse: A Dose Response Study with Long-Chain n-3 Fatty Acids,” Lipids, Vol. 27, No. 2, 1992, pp. 98-103. doi:10.1007/BF02535807

S. K. Abbott, P. L. Else and A. J. Hulbert, “Membrane Fatty Acid Composition of to the Balance of Dietary n-3 and Rat Skeletal Muscle Is Most Responsive n-6 PUPF,” British Journal of Nutrition, Vol. 103, No. 4, 2010, pp. 522-529. doi:10.1017/S0007114509992133

W. E. Lands, A. Morris and B. Libelt, “Quantitative Ef- fects of Dietary Polyunsaturated Fats on the Composition of Fatty Acids in Rat Tissues,” Lipids, Vol. 25, No. 9, 1990, pp. 505-516.

B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts and J. Watson, “Molecular Biology of the Cell,” 3rd Edition, Garland Science, New York, 1994, p. 428.

R. K. Murray, D. K. Granner, P. A. Mayes and P. A. Rodwell, “Harper’s Illustrated Biochemistry,” 26th Edi- tion, McGraw-Hill, New York, 2003, p. 97.

C. Guyton and J. E. Hall, “Textbook of Medical Physiol- ogy,” 9th Edition, W. B. Saunders Co., Philadelphia, 1996, pp. 16, 861-862.

H. Esterbauer, H. Puhl, M. Dieber-Rotheneder, G. Waeg and H. Rabi, “Effect of Antioxidants on Oxidative Modi- fication of LDL,” Annals of Medicine, Vol. 23, No. 5, 1991, pp. 573-581. doi:10.3109/07853899109150520

H. M. Sinclair, “Essential Fatty Acids in Perspective,” Human Nutrition. Clinical Nutrition, Vol. 38, No. 4, 1984, pp. 245-260. www.ncbi.nlm.nih.gov/pubmed/6469703

C. Guyton and J. E. Hall, “Textbook of Medical Physiol- ogy,” 9th Edition, W. B. Saunders Co., Philadelphia, 1996, pp. 872-873.

K. M. Bothem and P. A. Mayes, “Cholesterol Synthesis, Transport, and Excretion,” In: P. K. Murray, D. K. Gran- ner, P. A. Mayes and V. W. Rodwell, Eds., Harper’s Il- lustrated Biochemistry, 26th Edition, McGraw-Hill, New York, 2003, p. 235.

W. B. Zhang, P. B. Addis and T. P. Krick, “Quantifica- tion of 5a-Cholestane-3ß, 5, 6ß-Triol and Other Choles- terol Oxidation Products in Fast Food French Fried Pota- toes,” Journal of Food Science, Vol. 56, No. 3, 1991, pp. 716-718. doi:10.1111/j.1365-2621.1991.tb05364.x

W. Korytowski, G. J. Bachowski and A. W. Girotti, “Photoperoxidation of Cholesterol in Homogenous Solu- tion, Isolated Membranes, and Cells: Comparisons of the 5a- and 6ß-Hydroperoxides as Indicators of Singlet Oxy- gen Intermediacy,” Photochemistry and Photobiology, Vol. 56, No. 1, 1992, pp. 1-8. doi:10.1111/j.1751-1097.1992.tb09594.x

G. Spiteller, “Is Atherosclerosis a Multifactorial Disease or Is It Induced by a Sequence of Lipid Peroxidation Re-actions?” Annals of the New York Academy of Sciences, Vol. 1043, No. 1, 2005, pp. 355-366. doi:10.1196/annals.1333.042

G. Spiteller, “Peroxyl Radicals: Inductors of Neurode- generative and Other Inflammatory Diseases. Their Ori- gin and How They Transform, Cholesterol, Phospholipids, Plasmalogens, Polyunsaturated Fatty Acids, Sugars, and Proteins into Deleterious Products,” Free Radical Biology and Medicine, Vol. 41, No. 3, 2006, pp. 362-387. doi:10.1016/j.freeradbiomed.2006.03.013

C. Weiss, S. Regele, T. Velich, P. Bärtsch and T. Weiss, “Hemostasis and Fibrinolysis in Patients with Intermittent Claudication: Effects of Prostaglandin E1,” Prostagland- ins Leukotrienes and Essential Fatty Acids, Vol. 63, No. 5, 2000, pp. 271-277.

I. M. Campbell, D. N. Crozier and R. B. Caton, “Abnor- mal Fatty Acid Composition and Impaired Oxygen Sup- ply in Cystic Fibrosis Patients,” Pediatrics, Vol. 57, No. 4, 1976, pp. 480-486. doi:10.1054/plef.2000.0214

R. S. Chapkin, V. A. Ziboh, C. L. Marcelo and J. J. Voor- hees, “Metabolism of Essential Fatty Acids by Human Epidermal Enzyme Preparations: Evidence of Chain Elongation,” Journal of Lipid Research, Vol. 27, No. 9, 1986, pp. 945-954. www.ncbi.nlm.nih.gov/pubmed/3097227

A. Andersson, A. Sjodin, A. Hedman, R. Olsson and B. Vessby, “Fatty Acid Profile of Skeletal Muscle Phos- pholipids in Trained and Untrained Young Men,” Ameri- can Journal of Physiology—Endocrinology and Metabo- lism, Vol. 279, No. 4, 2000, pp. E744-E751. http://ajpendo.physiology.org/content/279/4/E744.short

G. Spiteller, “The Relation of Lipid Peroxidation Proc- esses with Atherogenesis: A New Theory on Atherogene- sis,” Molecular Nutrition & Food Research, Vol. 49, No. 11, 2005, pp. 999-1013. doi:10.1002/mnfr.200500055

U. N. Das, “A Defect in the Activity of D6 and D5 De- saturases May Be a Factor in the Initiation and Progres- sion of Atherosclerosis,” Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 76, No. 5, 2007, pp. 251-268. doi:10.1016/j.plefa.2007.03.001

S. D. Anton, K. Heekin, C. Simkins and A. Acosta, “Dif- ferential Effects of Adulterated versus Unadulterated Forms of Linoleic Acid on Cardiovascular Health,” Jour- nal of Integrative Medicine, Vol. 11, No. 1, 2013, pp. 2-10. doi:10.3736/jintegrmed2013002

GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitam,in E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999, 354:447-455

Van de Tempel et al.: Effects of fish oil supplementation in reumatoid arthritis. State University Groningen. The Netherlands. Ann Rheum Dis 1990 Feb;49(2):76-80

Shoda R. et al., Therapeutic efficiancy of n3 PUFA in experimental Cron´s disease. J Gasroenterol 1995, nov 30, suppl 8:98-101

Lassus A., et al: Effects of dietary supplementation with polyunsaturated ethyl ester lipids in patients with psoriasis and psoriatic arthritis. Dept. of Dermatology. University Central Hospital, Helsinki, Finnland. J Int ed Res 1990 Jan-Feb; 18(1):68-73 (a) Peet M., et.al., Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients and the clinical effects of dietary supplementation. Prostaglandins Leukot Esential Fatty acids 1996, Aug; 55(1-2):71-5 (b) Peet M, Horrobin D., et al., Depletation of omega-3 fatty acid eves in red blood cell membranes of depressive patients. Biol Psychiatry 1998 Mar 1; 43(5):315-9

Yazawa K.: Clinical experience with DHA in demented patients. International Conference on Highly Unsaturated Fatty Acids in Nutrition and Disease Prevention. Barcelona, Spain 1996, November 4-6.

Mitchell E.A. et al.,; Clinical characteristics and serum essential fatty acids levels in hyperactive children. Clin Pediatr (Phila) 1987 Aug;26(8):406-11

Nelson G.J.: The effect of dietary DHA on plasma lipoproteins and tissue fatty acid compositions in humans. USDA, San Francisco, California Lipids 1997 Nov; 32(11):1137-46

Haban P et al.: The effect of n3 acid administration on selected indicators of cv disease risk in patients with type 2 diabetes ellitus, Klinicke oddelente Vyskumneho ustavu vyzivy v Bratislave. Bratisl Lek Listy 1998, Jan 1999(1):37-42

(a) Caygill C. et al.: Fat, fish, fish oil and cancer. Br J Cancer 1996, 74(1):159-64 (b) Ohata T. et al.: Suppression of nitric oxide production in lipopolysaccharide-stimulated macrophage cells by Omega-3 PUFAs. J Cancer Res 1997 Mar;88(3):234-7 (c) Yam D., et al: Suppression of tumor growth and metastasis by dietary fish oil combined with vitamin E and C and cisplatin. Cancer Chemother. Pharmacol(.2001) 47:34-40

H. M. Sinclair, “Deficiency of Essential Fatty Acids and Atherosclerosis, Etcetera,” Lancet, Vol. 270, No. 6919, 1956, pp. 381-383. www.ncbi.nlm.nih.gov/pubmed/13307939

M. B. Katan, J. P. Deslypere, A. P. van Birgelen, M. Penders and M. Zegwaard, “Kinetics of the Incorporation of Dietary Fatty Acids into Serum Cholesteryl Esters, Erythrocyte Membranes, and Adipose Tissue: An 18-Month Controlled Study,” Journal of Lipids Research, Vol. 38, No. 10, 1997, pp. 2012-2022. www.ncbi.nlm.nih.gov/pubmed/9374124

H. Esterbauer, G. Jürgens, O. Quehenberger and E. Koller, “Autoxidation of Human Low Density Lipoprotein: Loss of Polyunsaturated Fatty Acids and Vitamin E and Gen- eration of Aldehydes,” Journal of Lipid Research, Vol. 28, 1987, pp. 495-509. www.jlr.org/content/28/5/495.full.pdf

A. A. Spector, “Plasma Free Fatty Acid and Lipoproteins as Sources of Polyunsaturated Fatty Acid for the Brain,” Journal of Molecular Neuroscience, Vol. 16, No. 2-3, 2001, pp. 159-165.

H. Kühn, J. Belkner, R. Wiesner, T. Schewe, V. Z. Lankin and A. K. Tikhaze, “Structure Elucidation of Oxy- genated Lipids in Human Atherosclerotic Lesions,” Ei- cosanoids, Vol. 5, 1992, pp. 17-22. www.ncbi.nlm.nih.gov/pubmed/1419075

C. V. Felton, D. Crook, M. J. Davies and M. F. Oliver, “Dietary Polyunsaturated Fatty Acids and Composition of Human Aortic Plaques,” The Lancet, Vol. 344, No. 8931, 1994, pp. 1195-1196. doi:10.1016/S0140-6736(94)90511-8

C. V. Felton, D. Crook, M. J. Davies and M. F. Oliver, “Relation of Plaque Lipid Composition and Morphology to the Stability of Human Aortic Plaques,” Arteriosclero- sis, Thrombosis, and Vascular Biology,” Vol. 17, No. 7, 1997, pp. 1337-1345. doi:10.1161/01.ATV.17.7.1337

S. Sethi, O. Ziouzenkova, H. Ni, D. D. Wagner, J. Plutzky and T. N. Mayadas, “Oxidized Omega-3 Fatty Acids in Fish Oil Inhibit Leukocyte-Endothelial Interactions through Activation of PPARa,” Blood, Vol. 100, No. 4, 2002, pp. 1340-1356. doi:10.1182/blood-2002-01-0316

S. G. Kaasgaard, S., G. Holmer, C.-E. Hoy, W. A. Beh- rens and J. L. Beare-Rogers, “Effects of Dietary Linseed Oil and Marine Oil on Lipid Peroxidation in Monkey Liver in Vivo and in Vitro,” Lipids, Vol. 27, No. 10, 1992, pp. 740-745. doi:10.1007/BF02535843

V. Bertele, C. Cerletti and G. de Gaetano, “Pathophysi- ology of Critical Leg Ischaemia and Mode of Action of Prostaglandins,” Prostaglandins in the Cardiovascular System: Proceedings of the 5th International “Symposium on Prostaglandins in the Cardiovascular System”, Vienna, 22-26 September 1991, pp. 18-26.

H. Knapp, I. Reilly, P. Alessandrini and G. A. FitzGerald, “In Vivo Indexes of Platelet and Vascular Function during Fish-Oil Administration in Patients with Atherosclerosis,” The New England Journal of Medicine, Vol. 314, No. 15, 1986, pp. 937-942. doi:10.1056/NEJM198604103141501

M. R. Buchanan, S. J. Brister and M. C. Bertomeu, “Ei- cosanoids, Other Fatty Acid Metabolites and the Cardio- vascular System: Are the Present Antithromobtic Ap- proaches Rational?” Prostaglandins in the Cardiovascu- lar System: Proceedings of the 5th International “Sympo- sium on Prostaglandins in the Cardiovascular System”, Vienna, 22-26 September 1991, pp. 18-26.

B. E. Karlström, A. E. Järvi, L. Byberg, L. G. Berglund and B. Vessby, “Fatty Fish in the Diet of Patients with Type 2 Diabetes: Comparison of the Metabolic Effects of Foods Rich in n-3 and n-6 Fatty Acids,” American Jour- nal of Clinical Nutrition, Vol. 94, No. 1, 2011, pp. 26-33. doi:10.3945/ajcn.110.006221

H. Glauber, P. Wallace, K. Griver and G. Brechtel, “Ad-verse Metabolic Effect of Omega-3 Fatty Acids in Non- Insulin-Dependent Diabetes Mellitus,” Annals of Internal Medicine, Vol. 108, No. 5, 1988, pp. 663-668. doi:10.7326/0003-4819-108-5-663

P. W. Stacpoole, J. Alig, L. Ammon and S. E. Crockett, “Dose-Response Effects of Dietary Marine Oil on Car- bohydrate and Lipid Metabolism in Normal Subjects and Patients with Hypertriglyceridemia,” Metabolism, Vol. 38, No. 10, 1989, pp. 946-956. doi:10.1016/0026-0495(89)90004-8

J. C. Umhau, W. Zhou, R. E. Carson, et al., “Imaging Incorporation of Circulating Docosahexaenoic Acid [DHA] into the Human Brain Using Positron Emission Tomography,” Journal of Lipid Research, Vol. 50, No. 7, 2009, pp. 1259-1268. doi:10.1194/jlr.M800530-JLR200

P. L. Goyens, M. E. Spilker, P. L. Zock, M. B. Katan, and R. P. Mensink, “Conversion of Alpha-Linolenic Acid in Humans Is Influenced by the Absolute Amounts of Al- pha-Linolenic Acid and Linoleic Acid in the Diet and Not by Their Ratio,” The American Journal of Clinical Nutrition, 2006, Vol. 84, No. 1, pp. 44-53.

N. Hussein, E. Ah-Sing, P. Wilkinson, C. Leach, B. Grif- fin and D. Millward, “Physiological Compartmental Analysis of Alpha-Linolenic Acid Metabolism in Adult Humans,” Journal of Lipid Research, Vol. 46, 2005, pp. 269-280. doi:10.1194/jlr.M400225-JLR200

F. Gao, H. Kim, M. Igarashi, et al., “Liver Conversion of Docosahexaenoic and Arachidonic Acids from Their 18-Carbon Precursors in Rats on a DHA-Free but -LNA-Containing n-3 PUFA Adequate Diet,” Bio- chimica et Biophysica Acta, Vol. 1811, No. 7-8, 2011 pp. 484-489. doi:10.1016/j.bbalip.2011.05.008

J. Cohn, S. Finkelstein S, G. McVeigh, et al., “Noninva- sive Pulse Wave Analysis for the Early Detection of Vascular Disease,” Hypertension, Vol. 26, No. 3, 1995, pp. 503-508.

J. Delarue, F. Labarthe and R. Cohen, “Fish-Oil Supple- mentation Reduces Stimulation of Plasma Glucose Fluxes during Exercise in Untrained Males,” British Medical Journal of Nutrition, Vol. 90, No. 4, 2003, pp. 777-786. doi:10.1079/BJN2003964

Volek, JS. Testosterone and cortisol in relationship to dietary nutrients and resistance exercise. Journal of Applied Physiology, Jan, 1999, 82

Garg, M L, Federation Of American Societies for Experimental Biology (FASEB) Journal, 1988, 2:4, “Meeting Abstracts,”American Oil Chemists Society Proceedings, May 1998, 7, Chicago, Il.

Emken EA, Dietary linoleic acid acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochemical Biophysical Acta, Aug 4, 1994; 1213 (3) 277-278.

Kabara, J J, The Pharmacological Effects Of Lipids, The American Oil Chemists Society, Champaign, IL, 1978, 1-14. Cohen, L A, Journal of the National Cancer Institute, 1986, 77:43.

Cha, Y S and D S Sachan, Journal of the American College of Nutrition, Aug 1994 13 (4): 338-43, Nanji, A A, Gastroenterology, Aug 1995, 109 (2) 547-54.

USDA National Database Nutrient Database for Standard Reference.

Conversations and mentorship with Dr Eric Serrano.

Conversations and interviews with Chris Masterjohn.

Cleveland LE, et al. 2000. Dietary intake of whole grains. J Am Coll Nutr 19 (3 Suppl):331S-38S.

Composition of Foods (Raw, Processed, Prepared): Agriculture Handbook No. 8. USDA Agricultural Research Service. 1963.

Cuskelly GJ, et al. 1996. Effect of increasing dietary folate on red-cell folate: implications for prevention of neural tube defects. Lancet 347:657-9.

Giovannucci E, et al. 1998. Multivitamin use, folate and colon cancer in women in the nurses’ health study. Ann Intern Med 129:517-24.

Manore MM, et al. 1989. Plasma pyridoxal 5’-phosphate concentration and dietary vitamin B-6 intake in free-living, low-income elderly people. Am J Clin Nutr 50:339-45.

Mansoor MA, et al. 1999. Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentrations of serum folate. Scand J Clin Lab Invest 59:139-46.

NPD Group, Inc. has a website at www.npd.com. Highlights from the 15th Annual Report on Eating Patterns in America are available online.

Organic Gardening’s letter to Dan Glickman, and the response of Phyllis E. Johnson of the USDA - see www.organicgardening.com.

Rimm EB, et al. 1998. Folate and Vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA 279:359-64.

Rose CS, et al. 1976. Age differences in vitamin B6 status of 617 men. Am J Clin Nutr 29:847-53.

Subar AF, et al. 1998. Dietary sources of nutrients among US adults, 1989 to 1991. J Am Diet Assoc 98:537-47.

Subar AF, et al. 1989. Folate intake and food sources in the US population. Am J Clin Nutr 50:508-16.

Rev Cubana Estomatol v.35 n.2 Ciudad deLa Habana Mayo-ago.1998

Prevention of Cancer and Cardiovascular diseases. J.M. Argiles. UB 1998.

Role of omega 3 fatty acids in health and disease. Gabriel Fernandes and Jaya T. Venkatraman. Nutrition research, Vol 13. 1993.

Evening Primrose oil and Borage oil in rheumatological conditions. Jill JF Belch. AJCN Vol. 71, nº 1. 2000.

Essential fatty acid metabolism and its modification in atopic eczema. D. F. Horrobin. AJCN Vol 71 Nº 1. 2000.

GLA treatment of rheumatoid arthritis. Arthritis Reum. 1996; 39. Zurier et al.

Price PT, Nelson CM, Clarke SD. Omega-3 polyunsaturated fatty acid regulation of gene expression. Curr Opin Lipidol. 2000;11(1):3-7.

The European Heart Network (EHN): Food, nutrition and cardiovascular disease prevention in the European region: challenges for the new millenium, 2002.

Bang HO, Dyerberg J, Sinclair HM: The composition of the Eskimo food in north western Greenland. Am J Clin Nutr 1980, 33:2657-61.

Sanders, TA: Polyunsaturated fatty acids in the food chain in Europe. Am J Clin Nutr 2000, 71:176S-180S.

Trautwein EA: n-3 fatty acids-physiological and technical aspects for their use in food. Eur J Lipid Sci Technol 2001, 103:45-55.

Hulshof KF, Van Erp-Baart MA, Anttolainen M y cols.: Intake of fatty acids in western Europe with emphasis on trans fatty acids: the Transfair Study. Eur J Clin Nutr 1999, 53:143-157. Hepburn FN, Exler J, Weihrauch JL: Provisional tables on the content of omega-3 fatty acids and other fat components of selected foods. J Am Diet Assoc 1986, 86:788-93. Kris-Etherton PM, Taylor DS, Yu-Poth S y cols.: Polyunsaturated fatty acids in the food chain in the United States. Am J Clin Nutr 2000, 71: 179S-188S.

Simopoulos AP, Leaf A, Salem N Jr.: Essentiality of and recommended

dietary intakes for omega-6 and omega-3 fatty acids. Am Nutr Metab 1999, 43:127-130.

Kris-Etherton PM, Harris WS, Appel LJ: AHA Nutrition Committee. American Heart Association: Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arterioscler Thromb Vasc Biol 2003, 23:151-2.

Aguilar Gonzalez, Ana E. Beneficios del Aceite de Onagra o Prímula, remedio femenino. inFÁRMAte,

año 1, número 5, enero-febrero 2006 . www.inFarmate.org.

Alonso, J. Tratado de Fitodermatología y Nutracéuticos . Ed Corpus 2004. pág 823-828.

Belch J.J., Ansell D, Madhok R, O'Dowd A, Sturrock R D. Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patiens with rheumatoid arthritis: a double blind placebo controlled study. Ann Rheum Dis 1988; 47:96-104

Belch J.J.F. and Muir A. n-6 and n-3 Essential fatty acid in rheumatoid arthritis and other rheumatic conditions.Proceedings of the Nutrition Society 1998, 57:563-569.

Berbis P, Hesse S, Privat Y . Essential fatty acids and the skin. Allerg Immunol 1990; 22 (6): 225-31

Budeiri D, li Wan Po A, Dornan J C. Is evening primrose oil of value in the treatment of premenstrual syndrome? Control Clin Trials 1996; 17 (1): 60-8.

Bourre J M., Dietary omega-3 fatty acids and psychiaty: mood, behaviour, stress, depression, demanti and aging. The Journal of Nutition, Health and Aging 2005, 9 (1): 31-38.

Bourre J M. Effects of nutrient ( in food) on the structure and function of the nervous system: Update on dietary requirements for brain. Part 2: Macronutrients . The Journal of Nutrition, Health & Aging 2006 10 ( 5): 386-399.

Cameron N E, Cotter M A. Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. Diabetes Sep 1997 ; 46 Suppl 2: S 31-7

Carretero Accame, M. E., Ortega Hernández- Agero, T, Villar del Fresno, A.M. Onagra Indicaciones terapéuticas. Farmacia Profesional 2002, 16 (10): 74-78.

Chung S., Kong S., Seong K. and Cho Y. Linolenic Acid in Borage Oil Reverses Epidermal

Hyperproliferation in Guinea Pigs. The Journal of Nutrition. 2002. 3090-3097.

Colter A.L., Cutler C., Meckling K.A. Fatty acid status and behavioural symptoms of Attention Deficit

Hyperactivity Disorder in adolescents: A case-control study. Nutrition Journal 2008, 7:8 doi:10.1186/1475-2891-7-8

D'Almeida A., Carter J.P., Anatol A, Prost C. Effects of a combination of evening primrose oil (gamma linolenic acid) and fish oil (eicosapentaenoic + docahexaenoic acid) versus magnesium, and versus placebo in preventing pre-eclampsia. Women Health 1992; 19 (2-3): 117-31

De La Cruz, J.P, Martin-Romero M, Carmona JA, Villalobos MA, Sanchez de la Cuesta F. Effect of evening primrose oil on platelet aggregation in rabbits fed an atherogenic diet. Thromb Res 1997, 87(1):141-9.

Deng, Y.C., Hua, H.M., Li, J., Lapinkase, P. Studies on the cultivation and uses of evening Primrose (Oenothera spp.) in China. Economic Botany 2001, 55(1): p83-92

Fei Lu and L Yeap Foo. Phenolic Antioxidant Components of Evening Primrose. A.S.H Ong, E. Niki and L Packer, Editors. Nutition, lipids, Health and Disease. Chapter 7, 86-95.

Ford I, Cotter M A, Cameron N E, Greaves M. The effects of treatment with alpha-lipoic acid or evening primrose oil on vascular hemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat. Metabolism 2001; 50 (8): 868-75

Gaby, A R., Natural remedies for scleroderma. Altern Med Rev. 2006, 11 (3): 188-95

Gamma-linolenic acid monograph. Alternative Medicine Review. 2004; (9): 70-78.

Gehring W, Bopp R, Rippke F, Gloor M. Effect of topically applied evening primrose oil on epidermal barrier function in atopic dermatitis as a function of vehicle. Arzneimittelforschung 1999 ;49 (7): 635-42

Ghasemnezhad , A. Tesis del Institute of Crop Science and Plant Breeding I Justus Liebig University

Giessen Prof. Dr. B. Honermeier "Investigations on the effects of harvest methods and storage conditions on yield, quality and germination of evening primrose (Oenothera biennis L.) seeds " Dissertation Submitted for the degree of Doctor of Agricultural Science (Dr. agr.) to the Faculty of Agricultural Sciences, Nutritional and Environmental Management Justus Liebig University. Giessen 2007

Griel A E, Kris-Etherton P M, Hilpert K F, Zhao G, Wets S G, Corwin R L. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. Nutrition Journal 2007, 6: 2


Harris N M, Crook T J, Dyer J P, Solomon L Z, Bass P, Cooper A J, Birch B R. Intravesical meglumine gamma-linolenic acid in superficial bladder cancer: an efficacy study. Eur Urol 2002, 42 (1): 39-42

Hederos C A., Berg A. Epogam evening primrose oil treatment in atopic dermatitis and asthma. Arch dis Child 1996 Dec; 75 (6): 494-7.

Honermeier, B., Ghasemnezhad, A., Beiten, S. Effect of different autumn and spring sowing times on seed yield and seed quality of evening primrose (Oenothera biennis L.). Journal of Medicinal and Spice Plants 2005, 10:187-193

Honermeier, B., Ghasemnezhad, A Yield, oil constituents, and protein content of evening primrose (Oenothera biennis L.) seeds depending on harvest time, harvest method and nitrogen application. Industrial Crops and Products 2008, 28 (1): 17-23

Josep Ma. Pla Dalmau. La Oenothers Biennis L. Revista Girona , 1969 (47) 22-28

Khoo Sk, Munro C., Battistutta D. Evening primrose oil and treatment of premenstrual syndrome. Med J Aust 1990 ; 153 (4): 189-92

Martindale the Extra Pharmacopoeia. The Royal Pharmaceutical Society. 31st Ed. pág 1708

Menendez JA, del Mar Barbacid M, MonteroS, et al. Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells. Eur J Cancer 2001; 37:402-413

Menendez J A, Lupu R, Colomer R. Exogenous supplementation with [omega]-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-

2/neu (c-erbB-2) oncogene expression in human breast cancer cells. European Journal of Cancer Prevention 2005; 14 (3) 263-270 Short communication

Morphake P., Bariety J., Darlametsos I., Tsipas G., Gkikas G., Hornysh A., Papanikolaou N. Alteration of cyclosporine (CsA)-induced nephrotoxicity by gamma linolenic acid (GLA) and eicosapentaenoic acid (EPA) in Wistar rats. Prostaglandins, Leukotrienes and Essential Fatty Acids 1994, Vol 50 (1): 29-35.

Morse N L, Clough P M. A meta-analysis of randomized, placebo-controlled clinical trials of Efamol evening primrose oil in atopic eczema. Where do we go from here in light of more recent discoveries? Curr Pharm Biotechnol 2006; 7 ( 6): 503-24

NazÝm ÞEKEROÚLU, Menßure OZGUVEN Effects of Different Nitrogen Doses and Row Spacing

Applications on Yield and Quality of Oenothera biennis L. Grown in Irrigated Lowland and Unirrigated

Dryland Conditions. Turk J Agric For.2006; 30: 125-135.

Puri B.K., The safety of evening primrose oil in epilepsy. Prostaglandins Leukot Essent Fatty Acids 2007; 77 (2): 101-103

Riaz A, Khan R A, Ahmed S P. Assesment of anticoagulant effect of evening primerose oil. Pak. J. Pharm. Sci 2009, 22 ( 4): 355-359

Richardson A J, Puri B K. The potential role of fatty acids in attention-deficit/hyperactivity disorder.prostaglandins Leukot Essent Fatty Acids 2000; 63 (1-2): 79-87

Schölkens B A, Gehring D, Schlotte V, Weithmann U. Evening primrose oil, a dietary prostaglandin precursor, diminishes vascular reactivity to renin and angiotensin II in rats.

Prostaglandins, Leukotrienes and Medicine 1982, 8 (3): 273-285

Senapati S, Banerjee S, Gangopadhyay DN. Evening primrose oil is effective in atopic dermatitis: arandomized placebo-controlled trial. Indian J Dermatol Venereol Leprol. 2008; 74(5):447-52.

Shahidi, F, Amarowicz R, He, Y., Wettasinghe M. Antioxidant activity of phenolic extracts of evening primrose ( Oenothera Biennis): a preliminary study. Journal of Food Lipids 2007. 4(2): 75-86.

Srivastava A, Mansel R E, Arvind N, Prasad K, Dhar A, Chabra A. Evidence-based management of Mastalgia: a meta-analysis of randomised trials. Breast Oct 2007 16 (5): 503-512

Sugano M., Ishida T., Takashi I. Effects of various polyunsaturated fatty acids on blood cholesterol and eicosanoids in rats. Agric. Bio. Chem 1986, 50 (9):2335-2340

Surette M E, Koumenis I L, Edens M B., Tramposch K M, Clayton B, Bowton D, Chilton F H.

Inhibition of leukotriene biosynthesis by a novel dietary fatty acid formulation in patients with atopic asthma: a randomized, placebo controlled, parallel-group, prospective trial. Clin Ther 2003; 25:972-979

Surette M E, Edens M, Chilton F H, Tramposch K M. Dietary Echium oil increases plasma and neutrophil long-chain (n-3) fatty accid and lowers serum triacylglycerols in hypertriglyceridemic humans. J. . Nutr 2004, 134: 1046-1411

Ulcerative Colitis Review. Inflammatory Bowel Disease Part 1: Ulcerative Colitis - Pathophysiology

and Conventional and Alternative Treatment Options. Alternative Medicine : Review 2003 ; 8 ( 3): 247-283.

USDA, NRCS. 2004. The PLANTS Database, Version 3.5 . http:// plants.usda.gov. National Plant Data Center, Baton Rouge, LA 70874-4490 USA

Van Gool, C. J A W, Zeegers, M P A, Thijs, C. Oral essential fatty acid supplementation in atopic

dermatitis—a meta-analysis of placebo-controlled trials. British Journal of Dermatology. 2004, 150 (4):728-740

Whitehouse P A, Cooper A J, Jphnson C D. Synergistic activity of gamma-linolenic acid and cytotoxic

drugs against pancreatic adenocarcinoma cell lines. Pancreatology 2003; 3 (5): 367-74

WHO Monographs on Selected Medicinal Plants. Volume 2. World Health Organization Geneva 2002. pág 217-230



Edwards BK, Howe HL, Ries LAG, et al. Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S. cancer burden. Cancer 2002; 94:2766-2792.

American Cancer Society, Cancer Statistics 2002, 2001, 2000, 1999, 1998, 1997. ACS’s annual estimates of expected numbers of new cancer cases and deaths.

Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists’ Collaborative Group. Lancet 1998; 351:1451-67.

Adlercreutz H, Van Der Wildt J, Kinzel J, et al. Lignan and isoflavanoid conjugates in human urine. Journal of Steroid Biochemistry and Molecular Biology 1995; 52:97-103.

Horn-Ross PL, Barnes S, Lee M, et al. Assessing phytoestrogen exposure in epidemiologic studies: development of a database (United States). Cancer Causes Control 2000; 11:289-98.

Marchbanks PA, McDonald JA, Wilson HG, et al. Oral contraceptives and the risk of breast cancer. N Engl J Med 2002; 346:2025-32.

Jacobs E, Kulling SE, Metzler M. Novel metabolites of the mammalian lignans enterolactone and enterodiol in human urine. J Steroid Biochem Mol Biol 1999; 68:211-8.

Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997; 17:353-81.

Nesbitt PD, Lam Y, Thompson LU. Human metabolism of mammalian lignan precursors in raw and processed flaxseed. American Journal of Clinical Nutrition 1999; 69:549-555.

Morton MS, Wilcox G, Wahlqvist ML, Griffiths K. Determination of lignans and isoflavonoids in human female plasma following dietary supplementation. Journal of Endocrinology 1994; 142:251-259.

Calvani M, Benatti P (2003) Polyinsaturated fatty acids(PUFA). Sigma-Tou S.P.A. 43pp.

Hornstra G (2000) Omega-3 long chain and health benefits. Maastricht University Traducción del original: Anselmino Catherine Centre d´Etude et d´information sur les vitamines Roche Vitamines rance Nevilly-Sur-Seine 56pp

Simopoulos AP (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56:365-379.

Beaudoin F, Michaelson L, Hey S, Lewis M, Shewry P, Sayanova O (2000) Heterologus reconstituition in yeast of the polyinsaturated fatty acid biosynthetic pathway. Proc Natl Acad Sci USA 97:6421-6426.

Drexler H, Spiekermann P, Meyer A, Domergue F, Thorsten Z, Sperling P, Abbadi A, Heinz E (2003) Metabolic engineering of fatty acids for breeding of new oilseed crops: strategies, and problems and first results. J Plant Physiol 160:779 -802.

López A, García Moroto F (2000) Plants as 'chemical factories' for the production of polyunsaturated fatty acids. Biotechnol Adv 18:481-497. Denyer GS (2002) The renaissance of fat roles in membrane structure signal transduction and gene expression. Med J Australia 176:S109.

Uauy R, Mena P (2001) Lipids and neurodeveploment. Nutr Rev. 59:534-546. Raclot T (2003) Selective obilization of fatty acids from adipose tissue triacylglicerols. Prog Lipid Res 42:257-288.

Gylling H, Miettinen T (2001) A review of clinical trials in dietary interventions to decrease the incidence of coronary artery disease. Curr Contr Trials C 2:123-128.

Hu F, Cho E, Rexrode K, Albert Ch, Manson J (2003) Fish and long chain w-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic woman. Circulation 107:1852-1857.

Hardman WE (2002) Omega-3 fatty acids to augment cancer therapy. Symposium International Conference on food, nutrition & cancer July 11-12 Washington.

Mantzioris E, Cleland LG, Gibson R, Neumann M, Demasi M, James M (2000) Biochemical effects of a diet containing foods enriched with n-3 fatty acids. Amm J Clin Nutr 72:42-48.

Stoll AL, Locke CA, Marangell LB, Severus WE (1999) Omega-3 fatty acids and bipolar disorder: a review. Prostag Leukotr Ess 60:329-337.

De Busk R, Hart JA, Kracoff G, Ottariano S (2004) (Review). Maryland Medical Center Programs.

Sindelar C, Scheerger S, Plugge Sh, Eskridge K, Wander R, Lewis N (2004) Serum lipids of physically active adults consuming omega-3 fatty acid enriched eggs or conventional eggs. Nut Res 24:731-739.

Logan AC (2003) Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression. Altern Med Rev 8:410-425.

Contreras MA, Rapaport SI (2002) Recent studies on interactions between n-3 and n-6 polyunsaturated fatty acids in brain and other tissues. Curr Opin Lipidol 13:267-272.

Brenner RR (2003) Hormonal modulation of delta 6 and delta 5 desaturases: Case of diabetes. Prostag Leukotr Ess 68:151-162.

Goodfellow J, Bellamy MF, Ramsey MW, Jones CJH, Lewis MJ (2000) Dietary supplementation with marine omega-3 fatty acids improve in subjects with hypercholesterolemia. J Am Coll Cardiol 35:265-70

The Journal of Nutritional Biochemistry October 2011

American Journal of Clinical Nutrition March 11, 2009: 89(6); 1857-1863.

American Journal of Clinical Nutrition, 86(5), 1420-1425, November 2007

The Organic & Non-GMO Report July 21, 2011


Wei Sheng Yan Jiu/Journal of Hygiene Research September 2011;40(5):551-4.

USNutra.com Astaxanthin

ConsumerLab.com, Supplement Use Report 2010

American Beekeeping Federation

Nimptsch K, Rohrmann S and Linseisen J. "Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)" Am J Clinical Nutrition April 2008;87(4):985-992

Association of Marine Omega-3 Fatty Acid Levels With Telomeric Aging in Patients With Coronary Heart Disease. "Asociación de los niveles de ácidos grasos marinos Omega-3 con el envejecimiento telomérico en pacientes con enfermedad coronaria". R. Farzaneh-Far, J. Lin, E.S. Epel, W.S. Harris, Elizabeth H. Blackburn, Mary A. Whooley. JAMA 2010;303(3):250-57.